日本比較内分泌学会 会員のみなさま
日本医科大学の長谷部会員より、ミシガン大学のDr. Robert Denverラボのポスドク募集の案内をいただきました。詳細は下記をご覧下さい。
庶務幹事 兵藤 晋
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差出人: Robert Denver
日付: August 1, 2015 at 1:09:59 AM GMT+9
宛先: Robert Denver
Please find attached and pasted below an announcement for postdoctoral opportunities at the University of Michigan. I would appreciate if you would communicate this to any qualified applicants. Thank you.
Best wishes,
Bob
Robert J. Denver, PhD
Professor and Chair, Department of Molecular, Cellular and Developmental Biology (MCDB), The University of Michigan, Ann Arbor http://www.lsa.umich.edu/mcdb/
MCDB Chair's office: 1127 Kraus Natural Science Building
Phone: 734-647-0893
FAX: 734-615-6337
Professor, Department of Ecology and Evolutionary Biology (EEB), The University of Michigan, Ann Arbor http://www.lsa.umich.edu/eeb/
President, International Federation of Comparative Endocrine Societies (IFCES)
Postdoctoral positions in developmental neuroendocrinology, epigenetics and gene regulation are available in the Department of Molecular, Cellular and Developmental Biology (MCDB) at the University of Michigan, Ann Arbor. The University of Michigan is among the top research institutions in the world, with outstanding opportunities for career development. The research laboratories, biomedical research core facilities, infrastructure, and computer technology at Michigan are state-of the art. We are now building a state-of-the-art life science research building, the Biological Sciences Building (BSB) which will house the Departments of MCDB and Ecology and Evolutionary Biology, the Museum of Paleontology and the public Museum of Science and Nature.
There are two projects with open postdoctoral positions:
1) Genome-wide analysis of DNA methylation and its regulation by hormones during post-embryonic brain development. This NSF-funded project is focused on: 1) genome-wide patterns of DNA methylation (methylome) during brain development and how these influence gene expression, 2) how DNA methylation in the developing brain is regulated by thyroid hormone (TH), and 3) the roles and mechanisms of ten eleven transferase (TET) enzymes in DNA demethylation and gene regulation in the developing brain. For this project we are using tadpoles of Xenopus species, and techniques that include chromatin immunoprecipitation sequencing (ChIP-seq), RNA sequencing (RNA-seq), methylome analysis, bioinformatics, bisulfite sequencing, transgenesis and CRISPR/Cas9-mediated genome editing in vivo.
2) Thyroid hormone regulation of DNA methylation in the developing brain through direct modulation of the DNA methyltransferase 3a gene. This NIH-funded project will investigate thyroid hormone (TH) regulation of Dnmt3a, and its role in neurological development. The goals of the project are to investigate: 1) the regulation of Dnmt3a by TH in mouse brain during early postnatal development, and 2) the role of Dnmt3a in TH-dependent cell cycle arrest and differentiation. For this project we are using wild type and mutant (thyroglobulin knockout) mice and mouse neuronal cell lines, and techniques that include cell transfection, chromatin immunoprecipitation sequencing (ChIP-seq), RNA sequencing (RNA-seq), methylome analysis, bioinformatics, bisulfite sequencing and CRISPR/Cas9-mediated genome editing.
A Ph.D. in an appropriate life science discipline such as developmental biology, neuroscience, neuroendocrinology, endocrinology, molecular biology is required. Send expressions of interest along with a CV and the names of three references to: Prof. Robert Denver, Department of MCDB, The University of Michigan, Ann Arbor, MI 48109-1048 (rdenver@umich.edu).
For more information please visit the lab website at: http://sites.lsa.umich.edu/denver-lab/
Keywords: neuroendocrinology, epigenetics, gene regulation, DNA methylation, developmental biology, Xenopus, mouse
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